Human Calcitonin Receptor (CALCR) ELISA Kit
546€ (96 tests)
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name
Human Calcitonin Receptor (CALCR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx351378
tested applications
ELISA
Description
Human Calcitonin Receptor (CALCR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Calcitonin Receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Calcitonin Receptor (CALCR) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | 0.1 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P30988 |
| Alias | CRT, CT-R, CTR, CTR1 |
| Background | Elisa kits for CALCR |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Calcitonin Receptor (CALCR) is a G-protein-coupled receptor that mediates the actions of calcitonin, a hormone primarily involved in calcium homeostasis and bone metabolism. CALCR is predominantly expressed in osteoclasts, where it inhibits bone resorption by reducing osteoclast activity and survival, thus maintaining bone mineral density. This function is critical for conditions like osteoporosis, where dysregulated bone turnover leads to bone fragility. Beyond bone health, CALCR is also expressed in the kidneys, where it enhances renal calcium excretion to regulate systemic calcium levels. Additionally, CALCR signaling in the central nervous system influences appetite regulation and energy metabolism, providing potential roles in managing obesity and metabolic disorders. CALCR is activated not only by calcitonin but also by related peptides, such as amylin, which are involved in glucose homeostasis and insulin secretion. Importantly, CALCR has been implicated in cancer progression, particularly in bone metastasis, where calcitonin receptor expression correlates with increased osteoclast activity and skeletal degradation. Dysregulation of CALCR signaling is also associated with diseases like Paget's disease and hypercalcemia of malignancy, where excessive calcium release disrupts homeostasis. Therapeutically, calcitonin analogs and CALCR-targeted drugs are widely used for treating osteoporosis, hypercalcemia, and bone pain. Emerging research suggests that CALCR may have broader roles in cardiovascular and neurodegenerative conditions, further underscoring its biological versatility and therapeutic potential.
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