Human CALCB Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human CALCB (P10092) (Met1-Phe118) was fused with Fc region of mouse IgG at the C-terminus.
Calcitonin gene-related peptide, (CGRP) is a neuropeptide secreted and stored in the nervous system. In humans, CGRP exists in two forms: CGRP alpha (α-CGRP or CGRP I), a 37-amino acid neuropeptide produced through alternative splicing of the CALCA gene (CALC1) and CGRP beta (β-CGRP or CGRP II), which is encoded by a separate, nearby gene known as CALCB (CALC2). These two forms differ only by three amino acids.N-terminal disulfide bond and an amidated C-terminus and allows CGRP to bind to its receptorCGRP has a protective role in various cardiovascular diseases and its involvement in migraines has also been proven. Additionally, it has been discovered that CGRP serves as a crucial link between the nervous system and the skeletal muscle system. CGRP plays a multifaceted role by promoting osteogenesis, inhibiting bone resorption, facilitating vascular growth, and regulating the immune microenvironment.
Proteins and Peptides
Human
HEK293 cells
Calcitonin Gene Related Peptide 2 / CGRP2 (CALCB)
HEK293 cells
SDS-PAGE
100 µg
Recombinant
> 95% (SDS-PAGE)
Lyophilized from sterile PBS, pH 7.4.
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
CALCB
No
Shipped within 5-15 working days.
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
Precio a consultar
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