Calcitonin gene-related peptide, (CGRP) is a neuropeptide secreted and stored in the nervous system. In humans, CGRP exists in two forms: CGRP alpha (α-CGRP or CGRP I), a 37-amino acid neuropeptide produced through alternative splicing of the CALCA gene (CALC1) and CGRP beta (β-CGRP or CGRP II), which is encoded by a separate, nearby gene known as CALCB (CALC2). These two forms differ only by three amino acids.N-terminal disulfide bond and an amidated C-terminus and allows CGRP to bind to its receptorCGRP has a protective role in various cardiovascular diseases and its involvement in migraines has also been proven. Additionally, it has been discovered that CGRP serves as a crucial link between the nervous system and the skeletal muscle system. CGRP plays a multifaceted role by promoting osteogenesis, inhibiting bone resorption, facilitating vascular growth, and regulating the immune microenvironment.
El péptido relacionado con el gen de la calcitonina (CGRP) es un neuropéptido secretado y almacenado en el sistema nervioso. En humanos, el CGRP existe en dos formas: CGRP alfa (α-CGRP o CGRP I), un neuropéptido de 37 aminoácidos producido mediante corte y empalme alternativo del gen CALCA (CALC1) y CGRP beta (β-CGRP o CGRP II), que está codificado por un gen cercano e independiente conocido como CALCB (CALC2). Estas dos formas se diferencian sólo por tres aminoácidos. Enlace disulfuro N-terminal y un extremo C amidado que permite que el CGRP se una a su receptor. El CGRP tiene un papel protector en diversas enfermedades cardiovasculares y también se ha demostrado su implicación en las migrañas. Además, se ha descubierto que el CGRP sirve como vínculo crucial entre el sistema nervioso y el sistema del músculo esquelético. El CGRP desempeña un papel multifacético al promover la osteogénesis, inhibir la resorción ósea, facilitar el crecimiento vascular y regular el microambiente inmunológico.
ELISA Kits
human
15.625-1000pg/ml
Sandwich ELISA, Double Antibody
Quantitative
Colorimetric
Serum,Plasma,Tissue homogenates,Other biological fluids
96T
CALCB|Calcitonin gene-related peptide 2|CALC2|Beta-CGRP|CGRP-II|Beta-type CGRP|Calcitonin gene-related peptide II
2-8 °C for 6 months
CALCB
This product is currently in development. The lead time for this product may be several months. Please contact us at inf...
775€ (1 ml)
Ver másHuman Calcitonin Gene Related Peptide 1 / CGRP1 (CALCA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurem...
556.25€ (96 tests)
Ver másCALCA/CGRP1 Antibody is a Rabbit Polyclonal against both calcitonin and CGRP1.
187.5€ (50 µg)
Ver más