Human C-Type Lectin Domain Family 4, Member K (CLEC4K) Protein
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Description
Human C-Type Lectin Domain Family 4, Member K (CLEC4K) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | C-Type Lectin Domain Family 4, Member K (CLEC4K) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 59.8 kDa Observed MW (SDS-PAGE): 60 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro65-Pro328 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | C-type lectin domain family 4 member K,CLEC4K,Langerin |
| Background | Protein CD207 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD207, commonly referred to as langerin, is a C-type lectin receptor primarily expressed in Langerhans cells (LCs), a specialized subset of dendritic cells residing in the epidermis and other epithelial surfaces, such as the respiratory and digestive tracts. CD207 plays a critical role in immune surveillance by recognizing and binding to specific carbohydrate structures on pathogens, facilitating their capture and internalization. This receptor is crucial for pathogen recognition and uptake, which supports the initiation of adaptive immune responses. Encoded by the CD207 gene, CD207 is instrumental in the function and identity of Langerhans cells. It is also the defining marker for Langerhans cells, distinguishing them from other dendritic cell subsets. Langerhans cells use CD207 to capture and internalize pathogens, leading to antigen processing and subsequent presentation to T cells, which is central to adaptive immunity. CD207’s unique feature is its ability to induce the formation of Birbeck granules—distinctive organelles with a rod and vesicle shape that are exclusive to Langerhans cells. These granules are believed to support the specialized antigen-processing function of CD207.
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