Human C-C Chemokine Receptor Type 6 (CCR6) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Human C-C Chemokine Receptor Type 6 (CCR6) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx493373
tested applications
CLIA
Description
Human Chemokine C-C-Motif Receptor 6 (CCR6) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | C-C Chemokine Receptor Type 6 (CCR6) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.054 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CCR6,CKR-L3,DCCR2,GPR-CY4,STRL22,DRY-6,GPR29,CD196,BN-1,C-C CKR-6,CC-CKR-6,CCR-6,CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22,C-C motif chemokine receptor 6 |
| Background | CLIA Kits CCR6 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
C-C Chemokine Receptor Type 6 (CCR6) is a G-protein-coupled receptor expressed on subsets of B cells, T-helper 17 (Th17) cells, regulatory T cells (Tregs), dendritic cells, and memory T cells. CCR6 binds its ligand CCL20 (MIP-3α) to regulate immune cell migration to sites of inflammation, infection, and mucosal tissues. It plays a pivotal role in mucosal immunity, promoting the trafficking of lymphocytes and dendritic cells to the gut-associated lymphoid tissue (GALT), where it contributes to host defense and immune homeostasis. CCR6 is essential for Th17 cell recruitment, which is critical for combating extracellular bacteria and fungi but can also drive autoimmune diseases like psoriasis, rheumatoid arthritis, and inflammatory bowel disease (IBD) when dysregulated. CCR6 also facilitates immune tolerance through its expression on Tregs, balancing pro-inflammatory and anti-inflammatory responses. In cancer, CCR6 is associated with tumor progression and metastasis, particularly in colorectal cancer and hepatocellular carcinoma, by mediating immune cell infiltration and fostering a tumor-permissive microenvironment. The CCR6-CCL20 axis has also been implicated in HIV infection, as CCR6+ T cells are preferential targets for viral replication. Targeting CCR6 and its signaling pathways holds therapeutic promise for autoimmune diseases, infectious diseases, and cancer immunotherapy. Ongoing research continues to elucidate its complex roles in immunity, inflammation, and disease pathology.
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