Human C-C Chemokine Receptor Type 5 (CCR5) Protein
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Description
Human Chemokine C-C-Motif Receptor 5 (CCR5) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | C-C Chemokine Receptor Type 5 (CCR5) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 9.7 kDa Observed MW (SDS-PAGE): 13/15 kDa Concentration: Prior to lyophilization: 150 µg/ml Sequence Fragment: Glu302-Leu352 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51681 |
| Gene ID | 1234 |
| OMIM | 601373 |
| Alias | CCR5,CHEMR13,CC CKR5,CKR5,CD195,MIP-1 alpha receptor,chemokine (C-C motif) receptor 5 (gene/pseudogene),C-C motif chemokine receptor 5 (gene/pseudogene),CCR-5,CCCKR5,CMKBR5,IDDM22 |
| Background | Protein CCR5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
C-C Chemokine Receptor Type 5 (CCR5) is a G-protein-coupled receptor expressed on the surface of macrophages, monocytes, T lymphocytes, and dendritic cells. CCR5 is a key player in immune surveillance and inflammatory responses, binding chemokines such as CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES) to mediate the chemotaxis and activation of immune cells. Importantly, CCR5 serves as a co-receptor for HIV-1 entry into host cells, making it a critical target in HIV/AIDS treatment. Individuals with a genetic CCR5Δ32 deletion exhibit resistance to HIV-1 infection, highlighting its role in viral pathogenesis. In addition to HIV, CCR5 contributes to immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where excessive chemokine signaling drives inflammation and tissue damage. CCR5 is also implicated in cancer progression, facilitating the recruitment of immune suppressive cells and metastasis by enhancing tumor-immune interactions. Therapeutic interventions targeting CCR5 include CCR5 antagonists like maraviroc, approved for treating HIV-1, and emerging therapies for autoimmune diseases and cancers. Recent studies also link CCR5 to recovery from stroke and neuroinflammation, highlighting its diverse roles in immunity, infection, and disease progression. Continued research on CCR5 biology may expand its applications in antiviral therapy, immunotherapy, and inflammatory disease management.
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