Human C-C Chemokine Receptor Type 5 (CCR5) ELISA Kit
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Description
Human C-C Chemokine Receptor Type 5 (CCR5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human C-C Chemokine Receptor Type 5 (CCR5) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Chemokine C-C-Motif Receptor 5 (CCR5)
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | C-C Chemokine Receptor Type 5 (CCR5) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.6 pg/ml - 1000 pg/ml |
| Sensitivity | < 5.90 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CCR5,CHEMR13,CC CKR5,CKR5,CD195,MIP-1 alpha receptor,chemokine (C-C motif) receptor 5 (gene/pseudogene),C-C motif chemokine receptor 5 (gene/pseudogene),CCR-5,CCCKR5,CMKBR5,IDDM22 |
| Background | Elisa kits for CCR5 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
C-C Chemokine Receptor Type 5 (CCR5) is a G-protein-coupled receptor expressed on the surface of macrophages, monocytes, T lymphocytes, and dendritic cells. CCR5 is a key player in immune surveillance and inflammatory responses, binding chemokines such as CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL5 (RANTES) to mediate the chemotaxis and activation of immune cells. Importantly, CCR5 serves as a co-receptor for HIV-1 entry into host cells, making it a critical target in HIV/AIDS treatment. Individuals with a genetic CCR5Δ32 deletion exhibit resistance to HIV-1 infection, highlighting its role in viral pathogenesis. In addition to HIV, CCR5 contributes to immune responses in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where excessive chemokine signaling drives inflammation and tissue damage. CCR5 is also implicated in cancer progression, facilitating the recruitment of immune suppressive cells and metastasis by enhancing tumor-immune interactions. Therapeutic interventions targeting CCR5 include CCR5 antagonists like maraviroc, approved for treating HIV-1, and emerging therapies for autoimmune diseases and cancers. Recent studies also link CCR5 to recovery from stroke and neuroinflammation, highlighting its diverse roles in immunity, infection, and disease progression. Continued research on CCR5 biology may expand its applications in antiviral therapy, immunotherapy, and inflammatory disease management.
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