Human Bcl2 Associated Athanogene 1 (BAG1) Protein

Este producto es parte de BAG - BAG cochaperone 1
Human Bcl2 Associated Athanogene 1 (BAG1) Protein

Pida mas información

935106861

info@markelab.com

Precio

169€ (10 µg)

Protein BAG1

proveedor

Abbexa

reference

abx650651

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human BAG1 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

BAG cochaperone 1 (BAG1) is a cochaperone protein that interacts with heat shock proteins (HSPs) to regulate protein folding, degradation, and cellular stress responses BAG1 plays a critical role in modulating the activity of HSP70 and HSP90, chaperone proteins that assist in the proper folding and stabilization of client proteins It facilitates protein degradation by interacting with the E3 ubiquitin ligase system, ensuring the removal of misfolded or damaged proteins under cellular stress BAG1 is involved in cell survival, apoptosis, and the regulation of cell signaling, particularly in response to oxidative stress and other damaging conditions It also interacts with transcription factors and signaling molecules to influence gene expression and cellular differentiation BAG1 has been implicated in various cancers, where it promotes tumor cell survival and resistance to chemotherapy by stabilizing key oncogenic proteins Additionally, BAG1’s role in apoptosis regulation and cellular stress responses highlights its potential as a therapeutic target for diseases related to protein misfolding, cancer, and neurodegeneration

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Bcl2 Associated Athanogene 1 (BAG1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 26.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr149-Glu345 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

BAG1


dry ice

No


availability

Shipped within 5-7 working days.


alias

HAP,BAG-1,RAP46,Bcl-2-associated athanogene 1,BAG family molecular chaperone regulator 1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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