Human Bcl2 Associated Athanogene 1 (BAG1) Protein

Pida mas información
935106861
info@markelab.com
Precio
169€ (10 µg)
Protein BAG1
proveedor
Abbexareference
abx650651Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human BAG1 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
BAG cochaperone 1 (BAG1) is a cochaperone protein that interacts with heat shock proteins (HSPs) to regulate protein folding, degradation, and cellular stress responses BAG1 plays a critical role in modulating the activity of HSP70 and HSP90, chaperone proteins that assist in the proper folding and stabilization of client proteins It facilitates protein degradation by interacting with the E3 ubiquitin ligase system, ensuring the removal of misfolded or damaged proteins under cellular stress BAG1 is involved in cell survival, apoptosis, and the regulation of cell signaling, particularly in response to oxidative stress and other damaging conditions It also interacts with transcription factors and signaling molecules to influence gene expression and cellular differentiation BAG1 has been implicated in various cancers, where it promotes tumor cell survival and resistance to chemotherapy by stabilizing key oncogenic proteins Additionally, BAG1’s role in apoptosis regulation and cellular stress responses highlights its potential as a therapeutic target for diseases related to protein misfolding, cancer, and neurodegeneration
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Bcl2 Associated Athanogene 1 (BAG1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 26.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr149-Glu345 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
BAG1
dry ice
No
availability
Shipped within 5-7 working days.
alias
HAP,BAG-1,RAP46,Bcl-2-associated athanogene 1,BAG family molecular chaperone regulator 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
anti- BAG1 antibody

proveedor
FineTestreference
FNab00786Tested Applications
ELISA, WB, IHC, IFreactivity
human,mousestatus
RUOclonality
polyclonalThe oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. T...
Precio a consultar
Ver másBAG Family Molecular Chaperone Regulator 1 (BAG1) Antibody

proveedor
Abbexareference
abx001023Tested Applications
ELISA, WB, IF/ICCreactivity
Human, Mousestatus
RUOclonality
PolyclonalBAG1 Antibody is a Rabbit Polyclonal antibody against BAG1. The oncogene BCL2 is a membrane protein that blocks a step i...
195€ (20 µl)
Ver másBAG Family Molecular Chaperone Regulator 1 (BAG1) Antibody

proveedor
Abbexareference
abx031785Tested Applications
ELISA, WB, IHC, IF/ICC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalBAG1 binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and ...
292.5€ (80 µl)
Ver más