Human B-Lymphocyte Antigen CD20 (MS4A1) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein MS4A1
proveedor
Abbexareference
abx654341Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Membrane Spanning 4 Domains Subfamily A, Member 1 (CD20) Protein is a Recombinant Human protein expressed in E. coli.
Background
MS4A1, also known as CD20, is a membrane-bound protein that plays a key role in the regulation of B-cell development, activation, and differentiation. It is predominantly expressed on the surface of B lymphocytes from the pre-B cell stage through to the mature B cell stage, and its expression is lost once B cells differentiate into plasma cells. CD20 is widely studied for its role in both normal immune function and its involvement in a variety of B-cell-related diseases, including non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL), and autoimmune diseases. MS4A1 is a member of the membrane-spanning 4A (MS4A) family of proteins, which includes several proteins with similar structural features, although their specific functions may differ across cell types and tissues. CD20 has become a major therapeutic target, particularly in B-cell depletion therapies, due to its restricted expression pattern and its role in the immune response. The development of anti-CD20 monoclonal antibodies, such as rituximab, has revolutionized the treatment of B-cell malignancies and certain autoimmune conditions.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
B-Lymphocyte Antigen CD20 (MS4A1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration up to 0.2 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 38.3 kDa Observed MW (SDS-PAGE): 43 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 50 µg/ml Sequence Fragment: Lys142-Pro297 Tag: N-terminal His and TrxA tags
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
MS4A1
dry ice
No
availability
Shipped within 5-12 working days.
alias
B1,S7,Bp35,CD20,FMC7,CVID5,LEU-16,B-lymphocyte antigen CD20,B-lymphocyte surface antigen B1,Leukocyte surface antigen Leu-16,Membrane-spanning 4-domains subfamily A member 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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