Human B-Cell Receptor CD22 / SIGLEC2 (CD22) Protein

Este producto es parte de CD22 - CD22 molecule
Product Graph
234€ (1 µg)

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935106861
info@markelab.com
name
Human B-Cell Receptor CD22 / SIGLEC2 (CD22) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680176
tested applications
SDS-PAGE

Description

Human B-Cell Receptor CD22 / SIGLEC2 (CD22) Protein is a recombinant protein produced in Sf9, Baculovirus cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
B-Cell Receptor CD22 / SIGLEC2 (CD22)
Host
Insect
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 85% (SDS-PAGE)
Size 1
1 µg
Size 2
5 µg
Size 3
50 µg
Form
Liquid 
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
Alias
SIGLEC2,SIGLEC-2,B-cell receptor CD22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,T-cell surface antigen Leu-14
Background
Protein CD22
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CD22, also known as Siglec-2, is a member of the sialic acid-binding immunoglobulin-like lectins (Siglec) family and is predominantly expressed on B cells. It plays a crucial role in modulating B-cell receptor (BCR) signaling and maintaining B-cell tolerance, making it an essential molecule in the regulation of the immune system. CD22 is primarily found on mature B cells, acting both as an inhibitory coreceptor to dampen BCR signaling and as an adhesion molecule involved in cell-cell interactions. CD22 is essential for maintaining the delicate balance between immune activation and tolerance, preventing excessive immune responses that could lead to autoimmune diseases. It is an inhibitory receptor that modulates B-cell activity by recruiting SHP-1, a phosphatase that negatively regulates B-cell signaling pathways. In this capacity, CD22 fine-tunes the immune response to antigens, ensuring that B cells are appropriately activated and preventing autoimmunity.

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