Human Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Protein (Active)
234€ (5 µg)
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935106861
info@markelab.com
name
Human Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx262195
tested applications
SDS-PAGE
Description
Human Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) Protein is an active recombinant human cytokine expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tumor Necrosis Factor Ligand Superfamily Member 13B / BAFF (TNFSF13B) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 17 kDa Sequence Fragment: Contains 153 amino acids. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE and RP-HPLC) |
| Purification | Purified by proprietary chromatographic techniques. 0.2 µm filtered prior to lyophilization. |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Lyophilized Reconstitute in sterile 18 MΩ · cm water to a concentration of at least 0.1 mg/ml. This stock solution can be further diluted if required. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.0. |
| Availability | Shipped within 5-10 working days. |
| Storage | Stable at room temperature for up to 3 weeks. Store below -18 °C for long-term storage. Upon reconstitution, store at 4 °C for up to 7 days and store below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y275 |
| Gene ID | 10673 |
| OMIM | 603969 |
| Alias | Tumor necrosis factor ligand superfamily member 13B,DTL,BAFF,BLYS,CD257,TALL1,THANK,ZTNF4,TALL-1,TNLG7A,TNFSF20,B lymphocyte stimulator,BLyS,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1 |
| Background | Protein TNFSF13B |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
TNFSF13B, commonly known as BAFF (B-cell activating factor), is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily and is critical for B cell survival, maturation, and immune function. This ligand is primarily produced by myeloid cells, such as monocytes, macrophages, and dendritic cells, but can also be secreted by activated T cells. BAFF plays a pivotal role in maintaining peripheral B cell populations, supporting antibody production, and promoting immune tolerance. It interacts with specific receptors on B cells and related immune cells, including BAFF-R, TACI (Transmembrane Activator and Calcium-Modulating Cyclophilin Ligand Interactor), and BCMA (B Cell Maturation Antigen), to initiate intracellular signaling pathways crucial for B cell homeostasis and function. Dysregulation of BAFF expression or receptor binding is associated with autoimmune diseases, such as systemic lupus erythematosus (SLE), multiple sclerosis, and rheumatoid arthritis.
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