Human Aurora Kinase B (AURKB) Protein
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Description
Aurora Kinase B Protein is a recombinant protein kinases.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aurora Kinase B (AURKB) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | Molecular Weight: 41.4 kDa. Sequence Fragment: 1-344 AA Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl buffer, pH 8.0, 0.5 mM DTT, 20% glycerol, 0.1 mM EDTA, 0.1 mM EGTA, 0.1 M NaCl and 0.1 mM PMSF. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store below -18°C. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96GD4 |
| Alias | AIK2,AIM1,AIRK2,ARK2,STK1,STK12,STK5,Serine/threonine-protein kinase 12 |
| Background | Protein AURKB |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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Aurora B(AURKB) is also named as aurora kinase B, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5 and belongs to the Aurora subfamily. Aurora kinase B is a chromosomal passenger serine/threonine protein kinase that regulates accurate chromosomal segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint(PMID:18311747). Expression levels of AURKB are increased in the anaplastic thyroid carcinoma cell lines ARO, Cal 62, and KAT-4(PMID:15562011).
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Aurora Kinase B (AURKB) Antibody
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004).[supplied by OMIM].
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Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1 (By similarity).
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