Human ATP-Citrate Synthase (ACLY) Protein
1118€ (50 µg)
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935106861
info@markelab.com
name
Human ATP-Citrate Synthase (ACLY) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693391
tested applications
SDS-PAGE
Description
ATP-Citrate Synthase (ACLY) protein is a recombinant Human protein expressed in Insect.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP-Citrate Synthase (ACLY) |
| Host | Insect |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Met1101 Tag: N-terminal His tag |
| Origin | Human |
| Observed MW | 123 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | P53396 |
| Alias | ACL,ATPCL,CLATP |
| Background | Protein ACLY |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
ATP-Citrate Synthase (ACLY) is a cytoplasmic enzyme that catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, a reaction powered by ATP hydrolysis. ACLY is a central player in cellular metabolism, linking energy production in the mitochondria with fatty acid and cholesterol biosynthesis. Acetyl-CoA generated by ACLY serves as a precursor for lipid synthesis and is essential for protein acetylation, including histone acetylation, which regulates gene expression. ACLY activity is upregulated in cancer cells to support rapid cell proliferation and metabolic reprogramming, making it a target for cancer therapy. Dysregulation of ACLY is also associated with metabolic diseases such as obesity, insulin resistance, and hyperlipidemia.
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