Human ATP Binding Cassette Transporter A3 (ABCA3) Protein

Este producto es parte de ABCA3 - ATP Binding Cassette Transporter A3
Human ATP Binding Cassette Transporter A3 (ABCA3) Protein

Pida mas información

935106861

info@markelab.com

Precio

225€ (10 µg)

Protein ABCA3

proveedor

Abbexa

reference

abx167134

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human ATP Binding Cassette Transporter A3 Protein is a recombinant Human protein expressed in E. coli. This protein is the immunogen for the following antibodies: abx128628


Background

ABCA3 is a critical protein in pulmonary surfactant production, predominantly expressed in alveolar type II epithelial cells in the lungs. It plays an essential role in transporting phospholipids and cholesterol into lamellar bodies, which are specialized organelles where surfactant is stored before secretion. ABCA3 utilizes ATP hydrolysis to facilitate lipid transport, ensuring the proper composition and function of surfactant, which reduces surface tension in the alveoli and prevents lung collapse. Mutations in the ABCA3 gene are associated with surfactant metabolism disorders, including neonatal respiratory distress syndrome and interstitial lung disease. These conditions are characterized by impaired surfactant production, leading to respiratory failure. ABCA3’s function in lipid transport and its critical role in pulmonary physiology underscore its importance in respiratory health.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

ATP Binding Cassette Transporter A3 (ABCA3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ABCA3


dry ice

No


availability

Shipped within 5-7 working days.


alias

ABC-C,ABC3,LBM180,SMDP3


note

This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.


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