Human ATP Binding Cassette Transporter A3 (ABCA3) Protein
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Description
Human ATP Binding Cassette Transporter A3 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATP Binding Cassette Transporter A3 (ABCA3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 34.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp1358-Phe1635 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99758 |
| Gene ID | 21 |
| OMIM | 601615 |
| Alias | ABC-C,ABC3,LBM180,SMDP3 |
| Background | Protein ABCA3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ABCA3 is a critical protein in pulmonary surfactant production, predominantly expressed in alveolar type II epithelial cells in the lungs. It plays an essential role in transporting phospholipids and cholesterol into lamellar bodies, which are specialized organelles where surfactant is stored before secretion. ABCA3 utilizes ATP hydrolysis to facilitate lipid transport, ensuring the proper composition and function of surfactant, which reduces surface tension in the alveoli and prevents lung collapse. Mutations in the ABCA3 gene are associated with surfactant metabolism disorders, including neonatal respiratory distress syndrome and interstitial lung disease. These conditions are characterized by impaired surfactant production, leading to respiratory failure. ABCA3’s function in lipid transport and its critical role in pulmonary physiology underscore its importance in respiratory health.
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