Human Atlastin 1 (ATL1) Protein

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Description
Human ATL1 Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human SPG3A (NP_056999.2) (Met 1-Thr 447) was fused with the GST tag at the N-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ATL1 |
| Host | Insect |
| Origin | Human |
| Observed MW | Molecular Weight: 77 kDa Sequence Fragment: Met1-Thr447 Tag: N-terminal GST tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 80% (SDS-PAGE) |
| Size 1 | 100 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 0.5mM EDTA, 0.5mM GSH, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_056999.2 |
| Alias | ARL3IP2,ARL6IP2,aip-2,atlastin2 |
| Background | Protein ATL1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
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