Human Aryl Hydrocarbon Receptor Interacting Protein (AIP) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein AIP
proveedor
Abbexareference
abx168881Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human AIP Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
The Aryl-hydrocarbon-interacting protein (AIP), also known as aryl hydrocarbon receptor-interacting protein, is a cellular protein that interacts with the aryl hydrocarbon receptor (AhR). AhR is a ligand-activated transcription factor that plays a crucial role in the regulation of gene expression in response to environmental toxins, such as dioxins, polycyclic aromatic hydrocarbons (PAHs), and other xenobiotics. AIP acts as a chaperone protein for AhR, assisting in its proper folding, stabilization, and nuclear translocation upon ligand binding. Through its interaction with AhR, AIP regulates the transcriptional activity of AhR-dependent genes involved in xenobiotic metabolism, detoxification, and other cellular processes. Mutations in the AIP gene are associated with a rare hereditary condition known as familial isolated pituitary adenoma (FIPA). Individuals with FIPA develop benign tumors of the pituitary gland, which can lead to hormonal imbalances and various health issues. These mutations disrupt the normal function of AIP, impairing its ability to interact with AhR and regulate its activity effectively.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Aryl Hydrocarbon Receptor Interacting Protein (AIP)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.4 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile63-Pro296 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AIP
dry ice
No
availability
Shipped within 5-7 working days.
alias
ARA9,FKBP16,FKBP37,PITA1,SMTPHN,XAP-2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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