Human Apolipoprotein A5 (APOA5) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein APOA5
proveedor
Abbexareference
abx065409Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Apolipoprotein A5 (APOA5) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
APOA5 is a critical regulator of plasma triglyceride (TG) levels, playing an essential role in lipid metabolism and cardiovascular health It is primarily synthesized in the liver and is a minor apolipoprotein component of chylomicrons and very-low-density lipoproteins (VLDL) APOA5 functions by enhancing the activity of lipoprotein lipase (LPL), which hydrolyzes triglycerides in VLDL and chylomicrons, thereby reducing plasma triglyceride levels Genetic variants in the APOA5 gene are strongly associated with hypertriglyceridemia, which is a major risk factor for cardiovascular diseases (CVD), atherosclerosis, and pancreatitis APOA5 interacts with cell surface receptors such as GPIHBP1 to facilitate LPL activity and triglyceride clearance from the bloodstream Studies have shown that reduced APOA5 expression leads to elevated triglycerides and increased risk of metabolic syndrome APOA5 also modulates lipid storage in adipose tissue, highlighting its broader role in lipid homeostasis APOA5 is being investigated as a therapeutic target for hyperlipidemia and related cardiovascular conditions, as strategies enhancing APOA5 expression or function may improve triglyceride metabolism and reduce cardiovascular risks
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Apolipoprotein A5 (APOA5)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 20.4 kDa Observed MW (SDS-PAGE): 20 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp167-Lys335 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl and 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
APOA5
dry ice
No
availability
Shipped within 5-7 working days.
alias
APOA5, APOAV, RAP3, apolipoprotein A5, APO A5,APO A-5,Apolipoprotein A-V
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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