Human Apolipoprotein A1 (APOA1) Protein
195€ (10 µg)
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name
Human Apolipoprotein A1 (APOA1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065398
tested applications
WB, SDS-PAGE
Description
Recombinant Apolipoprotein A1 (APOA1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Apolipoprotein A1 (APOA1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 18.5 kDa Observed MW (SDS-PAGE): 17 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln122-Gln267 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P02647 |
| Alias | Apo A1,Apo-A1,apo(a), apolipoprotein A1, Apolipoprotein A-I,HPALP2,APOA1,Apolipoprotein AI |
| Background | Protein APOA1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
APOA1 is the primary protein component of high-density lipoprotein (HDL), often referred to as "good cholesterol," where it plays a crucial role in reverse cholesterol transport. APOA1 facilitates the removal of cholesterol from peripheral tissues and delivers it to the liver for excretion via bile, thus protecting against atherosclerosis and cardiovascular disease. APOA1 is also an activator of lecithin-cholesterol acyltransferase (LCAT), an enzyme critical for HDL maturation and cholesterol esterification. Mutations in the APOA1 gene can result in familial HDL deficiency or amyloidosis, leading to cardiovascular dysfunction and systemic deposits of amyloid fibrils. As a key modulator of lipid metabolism, APOA1 is a major therapeutic target for managing dyslipidemia and reducing cardiovascular risk.
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