Human Apelin 12 (AP12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Apelin 12 concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Apelin, also known as APLN, is a peptide encoded by the APLN gene in humans. It serves as one of two endogenous ligands for the G-protein-coupled APJ receptor, which is expressed on the surface of many cell types. The Apelin gene encodes a pre-proprotein consisting of 77 amino acids, with a signal peptide at the N-terminal region. Translocation into the endoplasmic reticulum and cleavage of the signal peptide, the resulting protein, made up of 55 amino acids, can generate multiple active fragments. Apelin 36: A 36 amino acid peptide corresponding to the sequence 42-77. Apelin 17: A 17 amino acid peptide corresponding to the sequence 61-77. Apelin 13: A 13 amino acid peptide corresponding to the sequence 65-77. Ap-12, one of the most potent C-terminal fragments of this polypeptide, exhibits a high affinity for the orphan receptor APJ. Apelin-12 is involved in regulating body fluid homeostasis and plays a role in central control of feeding. Interestingly, Apelin-12 also has the ability to block HIV-1. Other aliases for apelin include APEL, XNPEP2, and apelin.
APELIN, también conocida como APLN, es un péptido codificado por el gen APLN en humanos. Actua como uno de los dos ligandos endógenos para el receptor APJ acoplado a proteína G, que se expresa en la superficie de muchos tipos de células. El gen Apelin codifica una preproproteína que consta de 77 aminoácidos, con un péptido señal en la región N-terminal. La translocación al retículo endoplásmico y la escisión del péptido señal, la proproteína resultante, compuesta por 55 aminoácidos, puede generar múltiples fragmentos activos. Apelina 36: Péptido de 36 aminoácidos correspondiente a la secuencia 42-77. Apelina 17: Péptido de 17 aminoácidos correspondiente a la secuencia 61-77. Apelina 13: Péptido de 13 aminoácidos correspondiente a la secuencia 65-77. Ap-12, uno de los fragmentos C-terminales más potentes de este polipéptido, muestra una alta afinidad por el receptor huérfano APJ. Apelin-12 participa en la regulación de la homeostasis de los fluidos corporales y desempeña un papel en el control central de la alimentación. Curiosamente, Apelin-12 también tiene la capacidad de bloquear el VIH-1. Otros alias de apelin incluyen APEL, XNPEP2 y apelin.
ELISA Kits
Apelin 12 (AP12)
Human
24.69 pg/ml - 2000 pg/ml
< 9.45 pg/ml
Competitive
Quantitative
Colorimetric
Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids
96 tests
5 × 96 tests
10 × 96 tests
AP12,APLN
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
AP12
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
Human Apelin 12 (AP12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Apelin 12 concentrat...
618.75€ (96 tests)
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