Human Anoctamin 1 (ANO1) Protein

Este producto es parte de ANO - Anoctamin
Human Anoctamin 1 (ANO1) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ANO1

proveedor

Abbexa

reference

abx655916

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Anoctamin 1 Protein is a recombinant Human protein expressed in E. coli.


Background

ANO1, also known as TMEM16A, is a calcium-activated chloride channel (CaCC) that plays a critical role in regulating chloride ion transport across membranes. It is widely expressed in epithelial cells, smooth muscle, and sensory neurons, where it regulates functions such as fluid secretion, smooth muscle contraction, and sensory transduction. ANO1 is essential for maintaining proper secretion of fluids and electrolytes in tissues such as the respiratory tract, salivary glands, and intestines. Dysregulation of ANO1 has been associated with diseases like cystic fibrosis, where chloride transport is impaired, as well as cancer, particularly in promoting tumor cell proliferation and migration. ANO1 also contributes to neuronal excitability and pain sensation, making it a potential therapeutic target in disorders involving abnormal ion transport and smooth muscle dysfunction.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Anoctamin 1 (ANO1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 42.2 kDa Observed MW (SDS-PAGE): 44 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ala333 Tag: N-terminal His tag


expression

Recombinant


purity

> 80%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ANO1


dry ice

No


availability

Shipped within 5-7 working days.


alias

ANO1,DOG1,ORAOV2,TAOS2,TMEM16A


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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