Human Annexin A7 (ANXA7) Protein
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Description
Human Annexin A7 Protein is a recombinant protein from Human produced in E. coli. Recombinant Human Annexin A7 is produced by our E.coli expression system and the target gene encoding Met1-Gln466 is expressed.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Annexin A7 |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 50.3 kDa Sequence Fragment: Met1-Gln466 |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 10mM TrisHCl, 100mM NaCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | P20073-2 |
| Alias | ANXA7,ANX7,SNX |
| Background | Protein ANXA7 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ANXA7 is a calcium- and GTP-dependent membrane-binding protein that plays a key role in exocytosis, membrane repair, and cell signaling. It acts as a calcium sensor, facilitating the fusion of vesicles with the plasma membrane, particularly in processes such as neurotransmitter release and hormone secretion. ANXA7 is expressed in the brain, heart, and other tissues, where it contributes to cellular calcium homeostasis and cell survival mechanisms. Mutations or dysregulation of ANXA7 have been associated with neurodegenerative diseases, such as Parkinson's disease, and cancers, where it can act as a tumor suppressor by regulating cell proliferation and apoptosis. Its roles in membrane dynamics and calcium-dependent signaling underscore its importance in cellular communication and homeostasis.
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Annexin A7(Anx7) belongs to a ubiquitous and relatively abundant family of Ca2+-dependent membrane-binding proteins, which are thought to be involved in multiple aspects of cell biology including membrane trafficking, mediation of cell-matrix interactions and membrane organization within cells. Anx7, migrated as a 50 kDa protein in SDS-PAGE, has been proposed to function in the fusion of vesicles, acting as a Ca++ channel and as Ca++-activated GTPase, thus inducing Ca++ /GTP-dependent secretory events.
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