Human Angiotensin I Converting Enzyme 2 (ACE2) CLIA Kit

Product specifications

CLIA Kits

Angiotensin I Converting Enzyme 2 (ACE2)

Human

Chemiluminescent

Quantitative

Sandwich

78 pg/ml - 5000 pg/ml

46.9 pg/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

CLIA

Serum, plasma and other biological fluids.

Shipped within 5-12 working days.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

ACEH,Peptidyl-Dipeptidase A

CLIA Kits ACE2

RUO

The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Angiotensin I Converting Enzyme 2 (ACE2) is a transmembrane protein that serves as a key regulator of the renin-angiotensin system (RAS) by catalyzing the conversion of angiotensin II (a potent vasoconstrictor) into angiotensin 1-7, which has vasodilatory, anti-inflammatory, and anti-fibrotic effects. ACE2 is highly expressed in the lungs, heart, kidneys, and gastrointestinal tract, and it plays a crucial role in maintaining cardiovascular and pulmonary homeostasis. Beyond its enzymatic function, ACE2 gained significant attention as the cellular entry receptor for the SARS-CoV and SARS-CoV-2 viruses, where it facilitates viral binding and internalization via interactions with the viral spike (S) protein. Dysregulation of ACE2 expression has been implicated in conditions such as hypertension, heart failure, acute lung injury, and COVID-19-related complications. Therapeutic strategies targeting ACE2, such as recombinant soluble ACE2 and RAS modulators, are being explored to counteract these pathologies. ACE2's dual role in regulating vascular function and serving as a viral receptor highlights its significance in both physiology and disease.

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Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. (Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV and human coronavirus NL63/HCoV-NL63.

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