Human Angiotensin-Converting Enzyme 2 (ACE2) Protein
299€ (50 µg)
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Name
Human Angiotensin-Converting Enzyme 2 (ACE2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx620021
Tested Applications
SDS-PAGE
Description
Human Angiotensin-Converting Enzyme 2 (ACE2) Protein is a recombinant protein expressed in Mammalian cells (Ser19-Ser740), containing a C-terminal His tag.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Angiotensin-Converting Enzyme 2 (ACE2) |
| Host | Mammalian cells |
| Assay Type | Activity: Not tested Sequence Fragment: Ser19-Ser740 Tag: C-terminal His tag |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 86.84 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 1 mM EDTA, 4% Trehalose and 1% Mannitol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20 °C to 80°C. Avoid repeated freeze-thaw cycles. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9BYF1 |
| NCBI Accession | NP_001358344.1 |
| Alias | ACEH,Peptidyl-Dipeptidase A |
| Background | Protein ACE2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to produce a stock solution. Concentration: Prior to lyophilization: 1 mg/ml |
Background
Angiotensin I Converting Enzyme 2 (ACE2) is a transmembrane protein that serves as a key regulator of the renin-angiotensin system (RAS) by catalyzing the conversion of angiotensin II (a potent vasoconstrictor) into angiotensin 1-7, which has vasodilatory, anti-inflammatory, and anti-fibrotic effects. ACE2 is highly expressed in the lungs, heart, kidneys, and gastrointestinal tract, and it plays a crucial role in maintaining cardiovascular and pulmonary homeostasis. Beyond its enzymatic function, ACE2 gained significant attention as the cellular entry receptor for the SARS-CoV and SARS-CoV-2 viruses, where it facilitates viral binding and internalization via interactions with the viral spike (S) protein. Dysregulation of ACE2 expression has been implicated in conditions such as hypertension, heart failure, acute lung injury, and COVID-19-related complications. Therapeutic strategies targeting ACE2, such as recombinant soluble ACE2 and RAS modulators, are being explored to counteract these pathologies. ACE2's dual role in regulating vascular function and serving as a viral receptor highlights its significance in both physiology and disease.
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