Human Angiopoietin-Related Protein 4 (ANGPTL4) Protein

Este producto es parte de ANGPTL - Angiopoietin Like
Human Angiopoietin-Related Protein 4 (ANGPTL4) Protein

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935106861

info@markelab.com

Precio

247€ (10 µg)

Protein ANGPTL4

proveedor

Abbexa

reference

abx065336

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant ANGPTL4 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ANGPTL4 is a secreted glycoprotein that plays key roles in lipid metabolism, angiogenesis, and inflammation. ANGPTL4 functions as an inhibitor of lipoprotein lipase (LPL), regulating triglyceride hydrolysis and fatty acid release, particularly during fasting and energy deprivation. It is expressed in adipose tissue, liver, and muscle, where it coordinates energy balance and lipid transport. ANGPTL4 also modulates angiogenesis by inhibiting endothelial cell proliferation and migration, making it a negative regulator of vascular growth. In cancer, ANGPTL4 has context-dependent roles, promoting metastasis by enhancing tumor cell migration and vascular permeability while inhibiting angiogenesis in certain conditions. Elevated ANGPTL4 levels are associated with obesity, diabetes, and atherosclerosis, where it contributes to dyslipidemia and chronic inflammation. Its ability to regulate lipid metabolism, angiogenesis, and inflammation makes ANGPTL4 a potential target for treating metabolic disorders, cardiovascular disease, and cancer.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Angiopoietin-Related Protein 4 (ANGPTL4)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 53.5 kDa Observed MW (SDS-PAGE): 53&35 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: His182-Tyr388 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ANGPTL4


dry ice

No


availability

Shipped within 5-7 working days.


alias

ARP4,FIAF,HARP,HFARP,NL2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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