Human Angiopoietin-Related Protein 3 (ANGPTL3) Protein

Este producto es parte de ANGPTL - Angiopoietin Like
Human Angiopoietin-Related Protein 3 (ANGPTL3) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ANGPTL3

proveedor

Abbexa

reference

abx065334

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant ANGPTL3 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ANGPTL3 is a secreted glycoprotein primarily expressed in the liver, where it plays a central role in regulating lipid metabolism. ANGPTL3 functions as an inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), leading to increased plasma levels of triglycerides, cholesterol, and low-density lipoproteins (LDL). It is a key regulator of systemic energy homeostasis, influencing lipid storage and transport under fasting and fed conditions. Genetic loss-of-function mutations in ANGPTL3 are associated with familial combined hypolipidemia, a condition characterized by significantly reduced levels of triglycerides, LDL, and HDL cholesterol, highlighting its critical role in lipid metabolism. ANGPTL3 is also implicated in cardiovascular diseases, where elevated levels are linked to atherosclerosis and coronary artery disease due to lipid accumulation and vascular inflammation. In cancer, ANGPTL3 promotes tumor angiogenesis and metastasis by regulating endothelial cell proliferation and migration. Its role as a regulator of lipid metabolism and vascular biology makes ANGPTL3 a promising therapeutic target for treating hyperlipidemia, atherosclerosis, and related metabolic disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Angiopoietin-Related Protein 3 (ANGPTL3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 23.0 kDa Observed MW: 25 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile10-Ile196 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ANGPTL3


dry ice

No


availability

Shipped within 5-7 working days.


alias

ANG-5,ANGPT5,ANL3,FHBL2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


Quizá le pueda interesar

Human ANGPTL3(Angiopoietin-related protein 3) ELISA Kit

Human ANGPTL3(Angiopoietin-related protein 3) ELISA Kit

proveedor

FineTest

reference

EH0598

reactivity

human

status

RUO

Precio a consultar

Ver más

anti- ANGPTL3 antibody

anti- ANGPTL3 antibody

proveedor

FineTest

reference

FNab00398

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is...

Precio a consultar

Ver más

Angiopoietin-Related Protein 3 (ANGPTL3) Antibody

Angiopoietin-Related Protein 3 (ANGPTL3) Antibody

proveedor

Abbexa

reference

abx000824

Tested Applications

ELISA, WB

reactivity

Mouse

status

RUO

clonality

Polyclonal

ANGPTL3 Antibody is a Rabbit Polyclonal antibody against ANGPTL3. Angiopoietin-Related Protein 3 (Angptl3) functions as ...

195€ (20 µl)

Ver más