Human Angiopoietin-2 (ANGPT2) ELISA Kit
643.5€ (96 tests)
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info@markelab.com
name
Human Angiopoietin-2 (ANGPT2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx150648
tested applications
ELISA
Description
Human Angiopoietin-2 (ANGPT2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Angiopoietin 2 concentrations in serum, plasma, saliva and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Angiopoietin 2
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Angiopoietin-2 (ANGPT2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 12.5 pg/ml - 800 pg/ml |
| Sensitivity | < 5.4 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, saliva and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O15123 |
| Gene ID | 285 |
| OMIM | 601922 |
| Alias | AGPT2,ANG2,LMPHM10 |
| Background | Elisa kits for ANGPT2 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANGPT2 is a secreted protein that functions as a context-dependent antagonist or agonist of the Tie2 receptor, depending on cellular and environmental conditions. ANGPT2 disrupts ANGPT1-Tie2 signaling under inflammatory or angiogenic conditions, leading to increased vascular permeability, endothelial activation, and vessel destabilization. ANGPT2 is expressed primarily in the vasculature, where it facilitates vascular remodeling during angiogenesis, inflammation, and tissue repair. It plays a key role in pathological angiogenesis observed in cancer, where it promotes the formation of abnormal, leaky blood vessels that support tumor growth and metastasis. ANGPT2 also acts as a regulator of inflammatory responses by enhancing endothelial activation and leukocyte recruitment. Elevated ANGPT2 levels are associated with diseases such as sepsis, diabetic vascular complications, and cardiovascular diseases, where excessive vascular permeability and endothelial dysfunction occur. ANGPT2 serves as a biomarker for vascular injury and a potential therapeutic target for stabilizing blood vessels in pathological conditions.
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