Human Angiomotin (AMOT) Protein

Background

AMOT or Angiomotin is a protein that in humans is encoded by the AMOT gene. Angiomotin is a scaffold protein that plays important roles in various cellular processes, including cell-cell junction formation, cell polarity, and regulation of signaling pathways involved in cell growth and migration. Angiomotin is involved in the assembly and maintenance of tight junctions, adherens junctions, and other cell-cell junctions. These junctions are critical for maintaining the integrity of tissues and regulating the passage of molecules between cells. AMOT is also important for establishing and maintaining cell polarity, which is crucial for the proper functioning of tissues and organs. Cell polarity refers to the asymmetric distribution of cellular components and structures within a cell. Angiomotin interacts with various signaling molecules and pathways to regulate processes such as cell growth, survival, and migration. For example, AMOT can interact with the Hippo signaling pathway, which is involved in controlling organ size and tumor suppression. Angiomotin has also been implicated in angiogenesis, It plays a role in the migration and organization of endothelial cells during blood vessel formation. Dysregulation of Angiomotin has been associated with various cancers. AMOT expression levels can affect the growth and invasive potential of cancer cells