Human Angiomotin (AMOT) Protein

Product specifications

Proteins and Peptides

Angiomotin (AMOT)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 13.8 kDa  Observed MW: 17 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Met1-Gln123
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

AMOT

Protein AMOT

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

AMOT or Angiomotin is a protein that in humans is encoded by the AMOT gene. Angiomotin is a scaffold protein that plays important roles in various cellular processes, including cell-cell junction formation, cell polarity, and regulation of signaling pathways involved in cell growth and migration. Angiomotin is involved in the assembly and maintenance of tight junctions, adherens junctions, and other cell-cell junctions. These junctions are critical for maintaining the integrity of tissues and regulating the passage of molecules between cells. AMOT is also important for establishing and maintaining cell polarity, which is crucial for the proper functioning of tissues and organs. Cell polarity refers to the asymmetric distribution of cellular components and structures within a cell. Angiomotin interacts with various signaling molecules and pathways to regulate processes such as cell growth, survival, and migration. For example, AMOT can interact with the Hippo signaling pathway, which is involved in controlling organ size and tumor suppression. Angiomotin has also been implicated in angiogenesis, It plays a role in the migration and organization of endothelial cells during blood vessel formation. Dysregulation of Angiomotin has been associated with various cancers. AMOT expression levels can affect the growth and invasive potential of cancer cells

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