Human Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ANAPC2
proveedor
Abbexareference
abx384584Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ANAPC2 concentrations in serum, plasma and other biological fluids.
Background
ANAPC2 is a core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) and functions as part of the catalytic module that regulates its E3 ubiquitin ligase activity. ANAPC2 interacts directly with ANAPC11, the RING finger protein, and facilitates the recruitment of E2 ubiquitin-conjugating enzymes to catalyze the transfer of ubiquitin onto substrates such as cyclin B, securin, and other key cell cycle regulators. This activity ensures the timely degradation of APC/C targets, driving the metaphase-to-anaphase transition and promoting exit from mitosis. ANAPC2 is critical for maintaining chromosomal stability and proper cell cycle progression. Dysregulation of ANAPC2 impairs APC/C activity, leading to mitotic defects, aneuploidy, and genomic instability, which are associated with cancer development and progression. Its catalytic role highlights ANAPC2 as a key player in cell division and a potential therapeutic target for controlling aberrant cell proliferation in cancers.
Características del producto
category
ELISA Kits
immunogen target
Anaphase Promoting Complex Subunit 2 (ANAPC2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.094 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma and other biological fluids.
size 1
96 tests
alias
ANAPC2,APC2,Cyclosome subunit 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ANAPC2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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