Human Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx384584
tested applications
ELISA
Description
Human Anaphase Promoting Complex Subunit 2 (ANAPC2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ANAPC2 concentrations in serum, plasma and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Anaphase Promoting Complex Subunit 2 (ANAPC2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UJX6 |
| Gene ID | 29882 |
| OMIM | 606946 |
| Alias | ANAPC2,APC2,Cyclosome subunit 2 |
| Background | Elisa kits for ANAPC2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANAPC2 is a core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) and functions as part of the catalytic module that regulates its E3 ubiquitin ligase activity. ANAPC2 interacts directly with ANAPC11, the RING finger protein, and facilitates the recruitment of E2 ubiquitin-conjugating enzymes to catalyze the transfer of ubiquitin onto substrates such as cyclin B, securin, and other key cell cycle regulators. This activity ensures the timely degradation of APC/C targets, driving the metaphase-to-anaphase transition and promoting exit from mitosis. ANAPC2 is critical for maintaining chromosomal stability and proper cell cycle progression. Dysregulation of ANAPC2 impairs APC/C activity, leading to mitotic defects, aneuploidy, and genomic instability, which are associated with cancer development and progression. Its catalytic role highlights ANAPC2 as a key player in cell division and a potential therapeutic target for controlling aberrant cell proliferation in cancers.
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