Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx502103
tested applications
ELISA
Description
Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 10 (ANAPC10) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Anaphase-promoting complex subunit 10 (ANAPC10) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UM13 |
| Alias | ANAPC10,APC10 |
| Background | Elisa kits for ANAPC10 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANAPC10 is a critical subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) and functions as a key adaptor in the ubiquitin ligase activity of the complex. ANAPC10 interacts with other core subunits, including CDC20 and CDH1, to facilitate the recruitment of substrates for ubiquitination. It helps target key cell cycle proteins such as cyclin B, securin, and geminin for proteasomal degradation, thereby driving progression through mitosis and maintaining proper cell cycle regulation. ANAPC10 also ensures the fidelity of chromosome segregation by preventing premature separation of sister chromatids. Dysregulation of ANAPC10 impairs APC/C activity, leading to chromosomal instability, mitotic arrest, and increased risk of cancer. It has been implicated in tumorigenesis due to its role in cell cycle checkpoint control and regulation of proliferation. Its function as an essential adaptor makes ANAPC10 a promising target for therapeutic strategies aimed at modulating mitotic progression in cancer cells.
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