Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit

Este producto es parte de ANAPC - Anaphase-promoting complex subunit
Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for ANAPC10

proveedor

Abbexa

reference

abx502103

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 10 (ANAPC10) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.


Background

ANAPC10 is a critical subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) and functions as a key adaptor in the ubiquitin ligase activity of the complex. ANAPC10 interacts with other core subunits, including CDC20 and CDH1, to facilitate the recruitment of substrates for ubiquitination. It helps target key cell cycle proteins such as cyclin B, securin, and geminin for proteasomal degradation, thereby driving progression through mitosis and maintaining proper cell cycle regulation. ANAPC10 also ensures the fidelity of chromosome segregation by preventing premature separation of sister chromatids. Dysregulation of ANAPC10 impairs APC/C activity, leading to chromosomal instability, mitotic arrest, and increased risk of cancer. It has been implicated in tumorigenesis due to its role in cell cycle checkpoint control and regulation of proliferation. Its function as an essential adaptor makes ANAPC10 a promising target for therapeutic strategies aimed at modulating mitotic progression in cancer cells.

Características del producto

category

ELISA Kits


immunogen target

Anaphase-promoting complex subunit 10 (ANAPC10)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.


size 1

96 tests


alias

ANAPC10,APC10


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ANAPC10


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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