Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ANAPC10
proveedor
Abbexareference
abx502103Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Anaphase-promoting complex subunit 10 (ANAPC10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 10 (ANAPC10) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
ANAPC10 is a critical subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) and functions as a key adaptor in the ubiquitin ligase activity of the complex. ANAPC10 interacts with other core subunits, including CDC20 and CDH1, to facilitate the recruitment of substrates for ubiquitination. It helps target key cell cycle proteins such as cyclin B, securin, and geminin for proteasomal degradation, thereby driving progression through mitosis and maintaining proper cell cycle regulation. ANAPC10 also ensures the fidelity of chromosome segregation by preventing premature separation of sister chromatids. Dysregulation of ANAPC10 impairs APC/C activity, leading to chromosomal instability, mitotic arrest, and increased risk of cancer. It has been implicated in tumorigenesis due to its role in cell cycle checkpoint control and regulation of proliferation. Its function as an essential adaptor makes ANAPC10 a promising target for therapeutic strategies aimed at modulating mitotic progression in cancer cells.
Características del producto
category
ELISA Kits
immunogen target
Anaphase-promoting complex subunit 10 (ANAPC10)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
ANAPC10,APC10
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ANAPC10
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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