Human Amyloid Precursor Protein, beta form (APPb) Protein
299€ (10 µg)
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935106861
info@markelab.com
name
Human Amyloid Precursor Protein, beta form (APPb) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx169317
tested applications
WB
Description
Human Amyloid Precursor Protein, beta form (APPb) Protein is a recombinant protein produced in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Amyloid Precursor Protein, beta form (APPb) |
| Host | HEK293 cells |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 67.3 kDa Observed MW (SDS-PAGE): 95 kDa Sequence Fragment: 18-596 AA (Isoform APP695). Tag: N terminal 10 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Size 1 | 10 µg |
| Size 2 | 25 µg |
| Size 3 | 50 µg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, containing 20% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05067-4 |
| Alias | AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,PN-II,preA4,CTFgamma,alpha-sAPP,Alzheimer disease amyloid protein |
| Background | Protein APP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
APP is a transmembrane glycoprotein widely expressed in the brain and peripheral tissues that plays a critical role in neuronal development, synaptic plasticity, and cell adhesion APP is proteolytically processed by enzymes such as α-secretase, β-secretase, and γ-secretase, leading to the production of various fragments, including the beta-amyloid (Aβ) peptide Abnormal processing of APP and the accumulation of Aβ peptides form amyloid plaques, which are a hallmark of Alzheimer’s disease and contribute to neurotoxicity and neurodegeneration APP also interacts with various proteins to mediate intracellular signaling and cellular responses Mutations in the APP gene are associated with early-onset familial Alzheimer’s disease, highlighting its role in the pathogenesis of neurodegenerative disorders
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