Human Amyloid Precursor Protein, alpha form (APPa) Protein
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935106861
info@markelab.com
Precio
287.5€ (10 µg)
Protein APP
proveedor
Abbexareference
abx169316Tested Applications
WBreactivity
status
RUOclonality
Descripción
Human Amyloid Precursor Protein, alpha form (APPa) Protein is a recombinant protein produced in HEK293 cells.
Background
APP is a transmembrane glycoprotein widely expressed in the brain and peripheral tissues that plays a critical role in neuronal development, synaptic plasticity, and cell adhesion APP is proteolytically processed by enzymes such as α-secretase, β-secretase, and γ-secretase, leading to the production of various fragments, including the beta-amyloid (Aβ) peptide Abnormal processing of APP and the accumulation of Aβ peptides form amyloid plaques, which are a hallmark of Alzheimer’s disease and contribute to neurotoxicity and neurodegeneration APP also interacts with various proteins to mediate intracellular signaling and cellular responses Mutations in the APP gene are associated with early-onset familial Alzheimer’s disease, highlighting its role in the pathogenesis of neurodegenerative disorders
Características del producto
category
Proteins and Peptides
origin
Human
host
HEK293 cells
immunogen target
Amyloid Precursor Protein, alpha form (APPa)
host
HEK293 cells
conjugation
Unconjugated
form
Liquid
tested applications
WB
size 1
10 µg
size 2
25 µg
size 3
50 µg
expression
Recombinant
purity
> 95% (SDS-PAGE)
purification
Purified by affinity chromatography.
buffer
PBS, containing 10% glycerol.
storage
Aliquot and store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles.
or code
APP
dry ice
No
availability
Shipped within 5-7 working days.
alias
AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,PN-II,preA4,CTFgamma,alpha-sAPP,Alzheimer disease amyloid protein
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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