Human Amyloid Precursor Protein, alpha form (APPa) Protein

Este producto es parte de APP - Beta-Amyloid Precursor Protein
Human Amyloid Precursor Protein, alpha form (APPa) Protein

Pida mas información

935106861

info@markelab.com

Precio

287.5€ (10 µg)

Protein APP

proveedor

Abbexa

reference

abx169316

Tested Applications

WB

reactivity

status

RUO

clonality

Descripción

Human Amyloid Precursor Protein, alpha form (APPa) Protein is a recombinant protein produced in HEK293 cells.


Background

APP is a transmembrane glycoprotein widely expressed in the brain and peripheral tissues that plays a critical role in neuronal development, synaptic plasticity, and cell adhesion APP is proteolytically processed by enzymes such as α-secretase, β-secretase, and γ-secretase, leading to the production of various fragments, including the beta-amyloid (Aβ) peptide Abnormal processing of APP and the accumulation of Aβ peptides form amyloid plaques, which are a hallmark of Alzheimer’s disease and contribute to neurotoxicity and neurodegeneration APP also interacts with various proteins to mediate intracellular signaling and cellular responses Mutations in the APP gene are associated with early-onset familial Alzheimer’s disease, highlighting its role in the pathogenesis of neurodegenerative disorders

Características del producto

category

Proteins and Peptides


origin

Human


host

HEK293 cells


immunogen target

Amyloid Precursor Protein, alpha form (APPa)


host

HEK293 cells


conjugation

Unconjugated


form

Liquid


tested applications

WB


size 1

10 µg


size 2

25 µg


size 3

50 µg


expression

Recombinant


purity

> 95% (SDS-PAGE)


purification

Purified by affinity chromatography.


buffer

PBS, containing 10% glycerol.


storage

Aliquot and store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles.


or code

APP


dry ice

No


availability

Shipped within 5-7 working days.


alias

AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,PN-II,preA4,CTFgamma,alpha-sAPP,Alzheimer disease amyloid protein


note

This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.


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