Human Amyloid Beta Precursor Protein Binding Protein A3 (APBA3) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein APBA3
proveedor
Abbexareference
abx652218Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Amyloid Beta Precursor Protein Binding Protein A3 (APBA3) Protein is a Recombinant protein from Human.
Background
APBA3, another member of the X11 protein family, is involved in the binding and regulation of the amyloid-beta precursor protein (APP). Unlike other members, APBA3 is highly expressed in a variety of tissues, including brain, heart, and liver, where it regulates both APP trafficking and protein stability. It binds APP through its phosphotyrosine-binding (PTB) domain and modulates its intracellular transport, preventing abnormal amyloid-beta production. APBA3 has additional roles beyond APP regulation, including its participation in vesicular transport, endocytosis, and regulation of apoptotic pathways. The protein is also implicated in immune regulation, where it interacts with components of the Toll-like receptor signaling pathway, suggesting a role in inflammatory responses. Dysregulation of APBA3 expression can contribute to amyloid plaque formation, mitochondrial dysfunction, and oxidative stress, particularly in neurodegenerative disorders such as Alzheimer’s disease. Furthermore, its involvement in cellular apoptosis suggests that APBA3 may also play a role in cancer progression and metabolic disorders. Understanding its mechanisms in APP metabolism and cellular signaling offers promising therapeutic opportunities to target neurodegenerative conditions and inflammatory processes.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Amyloid Beta Precursor Protein Binding Protein A3 (APBA3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 31.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp23-Leu278 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
APBA3
dry ice
No
availability
Shipped within 5-7 working days.
alias
APBA3, MGC:15815, X11L2, mint3, amyloid beta precursor protein binding family A member 3
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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