Human Amyloid Beta Precursor Protein Binding Protein A2 (APBA2) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein APBA2
proveedor
Abbexareference
abx167907Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
APBA2 Protein is a recombinant Human protein expressed in E. coli.
Background
APBA2 is a member of the X11 protein family, known for its role in interacting with the amyloid-beta precursor protein (APP). APBA2 is predominantly expressed in neuronal tissues, where it contributes to the regulation of APP trafficking, processing, and stabilization. This protein is involved in modulating amyloid-beta peptide production, a critical factor in Alzheimer’s disease pathology. By binding APP through its phosphotyrosine-binding (PTB) domain, APBA2 helps reduce the formation of amyloid-beta aggregates, which are the hallmark of neurodegeneration. Apart from its role in APP metabolism, APBA2 has been shown to participate in intracellular trafficking, synaptic vesicle function, and neuronal signal transduction pathways. Dysfunction of APBA2 may lead to abnormal APP processing, contributing to increased amyloid-beta deposition, oxidative stress, and neurotoxicity. Studies indicate that APBA2 is crucial for maintaining synaptic plasticity and cognitive functions, and its dysregulation may play a role in Alzheimer’s disease and other neurodegenerative disorders. As a molecular chaperone and stabilizer of APP, APBA2 is being explored as a potential therapeutic target to reduce amyloid plaque burden and preserve neuronal function in neurodegenerative diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Amyloid Beta Precursor Protein Binding Protein A2 (APBA2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 32.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Tyr459-Asn722 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
APBA2
dry ice
No
availability
Shipped within 5-7 working days.
alias
APBA2, D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, X11-BETA, X11L, amyloid beta precursor protein binding family A member 2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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