Human Amyloid beta 42 (Abeta42) Peptide (BSA)
442€ (100 µg)
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name
Human Amyloid beta 42 (Abeta42) Peptide (BSA)
category
Proteins and Peptides
provider
Abbexa
reference
abx651173
tested applications
WB, SDS-PAGE
Description
Amyloid beta 42 (Abeta42) Protein (BSA) is a Human protein conjugated to BSA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Amyloid beta 42 (Abeta42) |
| Origin | Human |
| Conjugation | BSA |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml |
| Expression | Synthetic |
| Purity | > 90% |
| Size 1 | 100 µg |
| Size 2 | 200 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Size 5 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Aβ42|Amyloid Beta 42|Aβ|1-42|Aβ1-42 |
| Background | Protein Abeta42 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Abeta42 is a 42-amino acid peptide that differs from Aβ40 by two additional residues at the C-terminal end, resulting in increased hydrophobicity and a greater propensity to aggregate into oligomers and fibrils. Aβ42 is a major component of the amyloid plaques found in Alzheimer’s disease, playing a critical role in its pathogenesis. Its aggregation disrupts neuronal membranes, induces oxidative stress, and triggers inflammatory responses, leading to synaptic dysfunction and neuronal death. Aβ42 is considered more neurotoxic than Aβ40 due to its higher aggregation potential and its ability to form soluble oligomers that impair synaptic signaling. The ratio of Aβ42 to Aβ40 in cerebrospinal fluid is a key biomarker for diagnosing and monitoring Alzheimer’s disease progression. Research is ongoing to understand the mechanisms of Aβ42 aggregation and its interactions with tau proteins, with the goal of developing therapeutic strategies targeting Aβ42 to mitigate Alzheimer’s-related neurodegeneration.
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