Human Amyloid Beta 42 (Abeta42) ELISA Kit
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935106861
info@markelab.com
Precio
618.75€ (96 tests)
Elisa Kits Abeta42
proveedor
Abbexareference
abx574166Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Amyloid Beta 42 (Abeta42) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Amyloid Beta 42 (Abeta42) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Amyloid beta 42 (Abeta42)No significant cross-reactivity or interference between Amyloid beta 42 (Abeta42) and analogues was observed.
Background
Abeta42 is a 42-amino acid peptide that differs from Aβ40 by two additional residues at the C-terminal end, resulting in increased hydrophobicity and a greater propensity to aggregate into oligomers and fibrils. Aβ42 is a major component of the amyloid plaques found in Alzheimer’s disease, playing a critical role in its pathogenesis. Its aggregation disrupts neuronal membranes, induces oxidative stress, and triggers inflammatory responses, leading to synaptic dysfunction and neuronal death. Aβ42 is considered more neurotoxic than Aβ40 due to its higher aggregation potential and its ability to form soluble oligomers that impair synaptic signaling. The ratio of Aβ42 to Aβ40 in cerebrospinal fluid is a key biomarker for diagnosing and monitoring Alzheimer’s disease progression. Research is ongoing to understand the mechanisms of Aβ42 aggregation and its interactions with tau proteins, with the goal of developing therapeutic strategies targeting Aβ42 to mitigate Alzheimer’s-related neurodegeneration.
Características del producto
category
ELISA Kits
immunogen target
Amyloid Beta 42 (Abeta42)
reactivity
Human
test range
3.7 pg/ml - 300 pg/ml
sensitivity
< 1.39 pg/ml
assay type
Competitive
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
Aβ42|Amyloid Beta 42|Aβ|1-42|Aβ1-42
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
Abeta42
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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