Human Amyloid beta 42 (Abeta42) CLIA Kit

Este producto es parte de Abeta42 - Amyloid beta 42
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643.5€ (96 tests)

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935106861
info@markelab.com
name
Human Amyloid beta 42 (Abeta42) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196432
tested applications
CLIA

Description

Human Amyloid beta 42 (Abeta42) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Amyloid beta 42 (Abeta42).

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryCLIA Kits
Immunogen TargetAmyloid beta 42 (Abeta42)
ReactivityHuman
Detection MethodChemiluminescent
Assay DataQuantitative
Assay TypeSandwich
Test Range12.5 pg/ml - 800 pg/ml
Sensitivity7.5 pg/ml
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
FormLyophilized
Tested ApplicationsCLIA
Sample TypeSerum, plasma and other biological fluids.
AvailabilityShipped within 5-12 working days.
Storage Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
AliasAβ42|Amyloid Beta 42|Aβ|1-42|Aβ1-42
BackgroundCLIA Kits Abeta42
StatusRUO
NoteThe validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Abeta42 is a 42-amino acid peptide that differs from Aβ40 by two additional residues at the C-terminal end, resulting in increased hydrophobicity and a greater propensity to aggregate into oligomers and fibrils. Aβ42 is a major component of the amyloid plaques found in Alzheimer’s disease, playing a critical role in its pathogenesis. Its aggregation disrupts neuronal membranes, induces oxidative stress, and triggers inflammatory responses, leading to synaptic dysfunction and neuronal death. Aβ42 is considered more neurotoxic than Aβ40 due to its higher aggregation potential and its ability to form soluble oligomers that impair synaptic signaling. The ratio of Aβ42 to Aβ40 in cerebrospinal fluid is a key biomarker for diagnosing and monitoring Alzheimer’s disease progression. Research is ongoing to understand the mechanisms of Aβ42 aggregation and its interactions with tau proteins, with the goal of developing therapeutic strategies targeting Aβ42 to mitigate Alzheimer’s-related neurodegeneration.

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