Human Amyloid beta 42 (Abeta42) CLIA Kit
643.5€ (96 tests)
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name
Human Amyloid beta 42 (Abeta42) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx196432
tested applications
CLIA
Description
Human Amyloid beta 42 (Abeta42) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Amyloid beta 42 (Abeta42).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Amyloid beta 42 (Abeta42) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 12.5 pg/ml - 800 pg/ml |
| Sensitivity | 7.5 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Aβ42|Amyloid Beta 42|Aβ|1-42|Aβ1-42 |
| Background | CLIA Kits Abeta42 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Abeta42 is a 42-amino acid peptide that differs from Aβ40 by two additional residues at the C-terminal end, resulting in increased hydrophobicity and a greater propensity to aggregate into oligomers and fibrils. Aβ42 is a major component of the amyloid plaques found in Alzheimer’s disease, playing a critical role in its pathogenesis. Its aggregation disrupts neuronal membranes, induces oxidative stress, and triggers inflammatory responses, leading to synaptic dysfunction and neuronal death. Aβ42 is considered more neurotoxic than Aβ40 due to its higher aggregation potential and its ability to form soluble oligomers that impair synaptic signaling. The ratio of Aβ42 to Aβ40 in cerebrospinal fluid is a key biomarker for diagnosing and monitoring Alzheimer’s disease progression. Research is ongoing to understand the mechanisms of Aβ42 aggregation and its interactions with tau proteins, with the goal of developing therapeutic strategies targeting Aβ42 to mitigate Alzheimer’s-related neurodegeneration.
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