Human AMP Deaminase 2 (AMPD2) ELISA Kit
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935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits AMPD2
proveedor
Abbexareference
abx385733Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human AMP Deaminase 2 (AMPD2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human AMPD2 concentrations in serum, plasma, cell culture supernatants and tissue homogenates.
Background
AMPD2 is an isoform of AMP deaminase predominantly expressed in the liver and brain, where it catalyzes the conversion of AMP to IMP as part of the purine nucleotide cycle. AMPD2 plays an essential role in hepatic energy metabolism, facilitating nucleotide turnover and maintaining purine homeostasis during conditions of energy stress. In the liver, AMPD2 activity is tightly linked to gluconeogenesis and urea cycle regulation, as it supplies intermediates such as fumarate for energy generation and ammonia detoxification. Mutations in AMPD2 are associated with pontocerebellar hypoplasia type 9 (PCH9), a severe neurodevelopmental disorder characterized by brain atrophy, microcephaly, and motor impairments due to disrupted purine metabolism. AMPD2 dysfunction leads to impaired nucleotide cycling, energy imbalance, and neuronal loss, highlighting its importance in brain development and function. Its role in liver metabolism and neurological health underscores its potential as a target for metabolic and neurodegenerative disorders.
Características del producto
category
ELISA Kits
immunogen target
AMP Deaminase 2 (AMPD2)
reactivity
Human
test range
125 pg/ml - 8000 pg/ml
sensitivity
< 49 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Tissue homogenates,,,,
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
AMP deaminase isoform L
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
AMPD2
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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