Human AMP Deaminase 2 (AMPD2) ELISA Kit

Este producto es parte de AMPD - AMP deaminase
Human AMP Deaminase 2 (AMPD2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

687.5€ (96 tests)

Elisa Kits AMPD2

proveedor

Abbexa

reference

abx385733

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human AMP Deaminase 2 (AMPD2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human AMPD2 concentrations in serum, plasma, cell culture supernatants and tissue homogenates.


Background

AMPD2 is an isoform of AMP deaminase predominantly expressed in the liver and brain, where it catalyzes the conversion of AMP to IMP as part of the purine nucleotide cycle. AMPD2 plays an essential role in hepatic energy metabolism, facilitating nucleotide turnover and maintaining purine homeostasis during conditions of energy stress. In the liver, AMPD2 activity is tightly linked to gluconeogenesis and urea cycle regulation, as it supplies intermediates such as fumarate for energy generation and ammonia detoxification. Mutations in AMPD2 are associated with pontocerebellar hypoplasia type 9 (PCH9), a severe neurodevelopmental disorder characterized by brain atrophy, microcephaly, and motor impairments due to disrupted purine metabolism. AMPD2 dysfunction leads to impaired nucleotide cycling, energy imbalance, and neuronal loss, highlighting its importance in brain development and function. Its role in liver metabolism and neurological health underscores its potential as a target for metabolic and neurodegenerative disorders.

Características del producto

category

ELISA Kits


immunogen target

AMP Deaminase 2 (AMPD2)


reactivity

Human


test range

125 pg/ml - 8000 pg/ml


sensitivity

< 49 pg/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Tissue homogenates,,,,


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

AMP deaminase isoform L


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

AMPD2


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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