Human Aminoadipate Semialdehyde Synthase (AASS) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein AASS
proveedor
Abbexareference
abx650211Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human AASS Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Alpha-aminoadipic semialdehyde synthase (AASS) is a bifunctional mitochondrial enzyme involved in the lysine degradation pathway. It catalyzes two sequential reactions: the oxidation of lysine to saccharopine via its lysine-ketoglutarate reductase activity and the subsequent conversion of saccharopine to alpha-aminoadipic semialdehyde via saccharopine dehydrogenase activity. This pathway plays a crucial role in amino acid catabolism and the production of acetyl-CoA, linking it to energy metabolism and the tricarboxylic acid (TCA) cycle. AASS is essential for maintaining lysine homeostasis and energy production, particularly under conditions of low glucose availability. Mutations in the AASS gene can lead to hyperlysinemia, a metabolic disorder characterized by elevated lysine levels in the blood and associated neurological symptoms. Emerging studies suggest AASS may also play a regulatory role in mitochondrial function and oxidative stress responses.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Aminoadipate Semialdehyde Synthase (AASS)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 50.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val33-Leu455 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
AASS
dry ice
No
availability
Shipped within 5-7 working days.
alias
LKRSDH,LORSDH,LKR/SDH
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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