Human Aminoadipate Semialdehyde Synthase (AASS) Protein

Este producto es parte de AASS - Alpha-aminoadipic semialdehyde synthase mitochondrial
Human Aminoadipate Semialdehyde Synthase (AASS) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein AASS

proveedor

Abbexa

reference

abx650211

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human AASS Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Alpha-aminoadipic semialdehyde synthase (AASS) is a bifunctional mitochondrial enzyme involved in the lysine degradation pathway. It catalyzes two sequential reactions: the oxidation of lysine to saccharopine via its lysine-ketoglutarate reductase activity and the subsequent conversion of saccharopine to alpha-aminoadipic semialdehyde via saccharopine dehydrogenase activity. This pathway plays a crucial role in amino acid catabolism and the production of acetyl-CoA, linking it to energy metabolism and the tricarboxylic acid (TCA) cycle. AASS is essential for maintaining lysine homeostasis and energy production, particularly under conditions of low glucose availability. Mutations in the AASS gene can lead to hyperlysinemia, a metabolic disorder characterized by elevated lysine levels in the blood and associated neurological symptoms. Emerging studies suggest AASS may also play a regulatory role in mitochondrial function and oxidative stress responses.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Aminoadipate Semialdehyde Synthase (AASS)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 50.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val33-Leu455 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AASS


dry ice

No


availability

Shipped within 5-7 working days.


alias

LKRSDH,LORSDH,LKR/SDH


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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