Human ALX Homeobox 1 (ALX1) ELISA Kit
715€ (96 tests)
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name
Human ALX Homeobox 1 (ALX1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385725
tested applications
ELISA
Description
Human ALX Homeobox 1 (ALX1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ALX1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | ALX Homeobox 1 (ALX1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q15699 |
| Gene ID | 8092 |
| OMIM | 601527 |
| Alias | ALX1,CART1,FND3,HEL23 |
| Background | Elisa kits for ALX1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALX1 is a homeobox transcription factor that plays a critical role in embryonic development, particularly in craniofacial morphogenesis. ALX1 regulates gene expression involved in mesenchymal cell differentiation and skeletal development. Mutations in ALX1 are associated with frontonasal dysplasia (FND), a congenital disorder characterized by craniofacial anomalies such as cleft palate, wide nasal bridge, and abnormal eye positioning (hypertelorism). ALX1 is essential for the proper formation of facial structures during early development, as it influences neural crest cell migration and differentiation into facial mesenchyme. Beyond craniofacial development, ALX1 has been implicated in limb and organ patterning. Dysregulation of ALX1 may result in developmental abnormalities, highlighting its importance as a key regulator of embryogenesis. Recent studies suggest ALX1 may also be involved in tissue regeneration and mesenchymal stem cell maintenance, broadening its functional significance.
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Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes(PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival(PubMed:20451171). May also induce epithelial to mesenchymal transition(EMT) through the expression of SNAI1(PubMed:23288509).
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