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Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits ALKBH2
proveedor
Abbexareference
abx501553Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ALKBH2 is a key DNA repair enzyme that catalyzes the direct reversal of methylated lesions, particularly N1-methyladenine (m1A) and N3-methylcytosine (m3C), in double-stranded DNA. It is part of the alpha-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase family, where it utilizes α-KG and molecular oxygen to demethylate damaged bases. ALKBH2 is essential for maintaining genomic integrity, as it repairs alkylation damage caused by environmental mutagens, chemotherapeutic agents, and endogenous metabolism. It operates in coordination with other DNA repair pathways to prevent mutations and DNA strand breaks. ALKBH2 is particularly active during DNA replication and cell division, ensuring faithful genome transmission. Mutations or dysregulation of ALKBH2 are associated with increased susceptibility to cancer and reduced cellular survival under genotoxic stress. Its function makes it a promising therapeutic target for enhancing the efficacy of alkylating agents in cancer treatment.
Características del producto
category
ELISA Kits
immunogen target
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
ALKBH2,ABH2
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
ALKBH2
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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