Human Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for AASS
proveedor
Abbexareference
abx500369Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Alpha-aminoadipic semialdehyde synthase (AASS) is a bifunctional mitochondrial enzyme involved in the lysine degradation pathway. It catalyzes two sequential reactions: the oxidation of lysine to saccharopine via its lysine-ketoglutarate reductase activity and the subsequent conversion of saccharopine to alpha-aminoadipic semialdehyde via saccharopine dehydrogenase activity. This pathway plays a crucial role in amino acid catabolism and the production of acetyl-CoA, linking it to energy metabolism and the tricarboxylic acid (TCA) cycle. AASS is essential for maintaining lysine homeostasis and energy production, particularly under conditions of low glucose availability. Mutations in the AASS gene can lead to hyperlysinemia, a metabolic disorder characterized by elevated lysine levels in the blood and associated neurological symptoms. Emerging studies suggest AASS may also play a regulatory role in mitochondrial function and oxidative stress responses.
Características del producto
category
ELISA Kits
immunogen target
Alpha-aminoadipic semialdehyde synthase, mitochondrial (AASS)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.12 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
LKRSDH,LORSDH,LKR/SDH
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AASS
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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