Human Alpha-1-Antichymotrypsin (SERPINA3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human alpha 1 Antichymotrypsin concentrations in serum, plasma and other biological fluids.
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine proteases, one of which is cathepsin G. Elevated levels of SERPINA3 have been observed in heart failure and neurological diseases such as Alzheimer’s disease
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). SERPINA3, también llamada α-1-antiquimotripsina (AACT, ACT), es uno de los inhibidores de las serina proteasas, una de las cuales es la catepsina G. Se han observado niveles elevados de SERPINA3 en insuficiencia cardíaca y enfermedades neurológicas como la enfermedad de Alzheimer.
ELISA Kits
Alpha-1-Antichymotrypsin (SERPINA3)
Human
0.6 ng/ml - 40 ng/ml
0.375 ng/ml
Sandwich
Quantitative
Colorimetric
Serum,Plasma,Other biological fluids
96 tests
ACT,AACT,GIG24,GIG25,Alpha-1-antichymotrypsin,Cell growth-inhibiting gene 24/25 protein,Serpin A3
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
SERPINA3
No
NP_001076.2, NM_001085.4
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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