Human Aldose Reductase (AKR1B1) ELISA Kit
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935106861
info@markelab.com
Precio
525€ (96 tests)
Elisa Kits AKR1B1
proveedor
Abbexareference
abx251502Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Aldose Reductase (AKR1B1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldose Reductase (AKR1B1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
AKR1B1, also known as aldose reductase, is a key enzyme in the polyol pathway that converts glucose to sorbitol under hyperglycemic conditions. It has a significant role in the pathogenesis of diabetic complications, such as neuropathy, nephropathy, and retinopathy, as sorbitol accumulation induces osmotic stress and oxidative damage. AKR1B1 also metabolizes reactive aldehydes, including lipid peroxidation products like 4-hydroxynonenal (4-HNE), contributing to cellular detoxification under oxidative stress. Its overactivation under diabetic and inflammatory conditions exacerbates oxidative stress and inflammatory signaling pathways. AKR1B1 inhibitors have been developed as potential therapeutic agents for managing diabetic complications. Beyond diabetes, AKR1B1 is involved in steroid metabolism and the detoxification of xenobiotics. It has also been implicated in cancer progression, as its expression is upregulated in some tumors, promoting proliferation and chemoresistance by reducing reactive aldehydes and maintaining cellular redox balance.
Características del producto
category
ELISA Kits
immunogen target
Aldose Reductase (AKR1B1)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
0.19 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
AKR1B1,ADR ALDR1,ALR2,AR
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
AKR1B1
dry ice
No
uniprot id
NCBI accession
NP_001619.1
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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