Human Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Protein

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Description
Human Aldo-Keto Reductase 1C3 Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Aldo-Keto Reductase Family 1 Member C3 is produced by our Mammalian expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the C-terminus.
Documents del producto
Product specifications
Category | Proteins and Peptides |
Immunogen Target | Aldo-Keto Reductase 1C3 |
Host | Human |
Origin | Human |
Observed MW | Molecular Weight: 37.8 kDa Sequence Fragment: Met1-Tyr323 Tag: C-terminal 6 His tag |
Expression | Recombinant |
Purity | > 95% (SDS-PAGE) |
Size 1 | 10 µg |
Size 2 | 50 µg |
Form | Lyophilized |
Tested Applications | SDS-PAGE |
Buffer | 20mM PB, 150mM NaCl, pH7.4. |
Availability | Shipped within 5-15 working days. |
Storage | Store at < -20°C. |
Dry Ice | No |
UniProt ID | P42330 |
Alias | AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS |
Background | Protein AKR1C3 |
Status | RUO |
Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AKR1C3, also known as 17β-hydroxysteroid dehydrogenase type 5, is a multifunctional enzyme involved in the metabolism of steroid hormones, prostaglandins, and xenobiotics. AKR1C3 converts androstenedione to testosterone and estrone to estradiol, playing a central role in androgen and estrogen biosynthesis. It also reduces prostaglandin D2 to PGF2α, influencing inflammation, immune responses, and cell proliferation. AKR1C3 is overexpressed in hormone-dependent cancers, such as prostate, breast, and endometrial cancers, where it promotes tumor growth by enhancing local androgen and estrogen production. Its ability to detoxify lipid peroxidation products like 4-HNE also confers resistance to oxidative stress and chemotherapy. AKR1C3 is emerging as a therapeutic target in cancer, particularly in castration-resistant prostate cancer, where it sustains androgen receptor signaling. In addition to cancer, AKR1C3 regulates neurosteroids and prostaglandin pathways, linking it to inflammation, neuroprotection, and metabolic diseases.
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This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha, 11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
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