Human Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Protein

Este producto es parte de AKR1C- Aldo-keto reductase family 1 member C
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338€ (10 µg)

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935106861
info@markelab.com
name
Human Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690403
tested applications
SDS-PAGE

Description

Human Aldo-Keto Reductase 1C3 Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Aldo-Keto Reductase Family 1 Member C3 is produced by our Mammalian expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Aldo-Keto Reductase 1C3
Host
Human
Origin
Human
Observed MW
Molecular Weight: 37.8 kDa
Sequence Fragment: Met1-Tyr323
Tag: C-terminal 6 His tag
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
10 µg
Size 2
50 µg
Form
Lyophilized 
Tested Applications
SDS-PAGE
Buffer
20mM PB, 150mM NaCl, pH7.4.
Availability
Shipped within 5-15 working days.
Storage
Store at < -20°C.
Dry Ice
No
UniProt ID
P42330
Alias
AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS
Background
Protein AKR1C3
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

AKR1C3, also known as 17β-hydroxysteroid dehydrogenase type 5, is a multifunctional enzyme involved in the metabolism of steroid hormones, prostaglandins, and xenobiotics. AKR1C3 converts androstenedione to testosterone and estrone to estradiol, playing a central role in androgen and estrogen biosynthesis. It also reduces prostaglandin D2 to PGF2α, influencing inflammation, immune responses, and cell proliferation. AKR1C3 is overexpressed in hormone-dependent cancers, such as prostate, breast, and endometrial cancers, where it promotes tumor growth by enhancing local androgen and estrogen production. Its ability to detoxify lipid peroxidation products like 4-HNE also confers resistance to oxidative stress and chemotherapy. AKR1C3 is emerging as a therapeutic target in cancer, particularly in castration-resistant prostate cancer, where it sustains androgen receptor signaling. In addition to cancer, AKR1C3 regulates neurosteroids and prostaglandin pathways, linking it to inflammation, neuroprotection, and metabolic diseases.

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