Human Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Enzyme
234€ (5 µg)
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Name
Human Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) Enzyme
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073557
Tested Applications
SDS-PAGE
Description
Aldo-Keto Reductase Family 1 Member C3 is a recombinant enzyme.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C3 (AKR1C3) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P42330 |
| Alias | AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS |
| Background | Protein AKR1C3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AKR1C3, also known as 17β-hydroxysteroid dehydrogenase type 5, is a multifunctional enzyme involved in the metabolism of steroid hormones, prostaglandins, and xenobiotics. AKR1C3 converts androstenedione to testosterone and estrone to estradiol, playing a central role in androgen and estrogen biosynthesis. It also reduces prostaglandin D2 to PGF2α, influencing inflammation, immune responses, and cell proliferation. AKR1C3 is overexpressed in hormone-dependent cancers, such as prostate, breast, and endometrial cancers, where it promotes tumor growth by enhancing local androgen and estrogen production. Its ability to detoxify lipid peroxidation products like 4-HNE also confers resistance to oxidative stress and chemotherapy. AKR1C3 is emerging as a therapeutic target in cancer, particularly in castration-resistant prostate cancer, where it sustains androgen receptor signaling. In addition to cancer, AKR1C3 regulates neurosteroids and prostaglandin pathways, linking it to inflammation, neuroprotection, and metabolic diseases.
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