Human Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Protein
338€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx694004
Tested Applications
SDS-PAGE
Description
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Tyr323 |
| Origin | Human |
| Observed MW | 36.7 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM TrisHCl, 100 mM NaCl, 1 mM DTT, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. Shelf Life: 6 months. |
| Dry Ice | No |
| UniProt ID | P52895 |
| Alias | AKR1C2,DDH2 |
| Background | Protein AKR1C2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
AKR1C2, known as 3α-hydroxysteroid dehydrogenase, catalyzes the reduction of 5α-dihydrotestosterone (DHT) to 3α-androstanediol, thereby inactivating this potent androgen. AKR1C2 is a key regulator of androgen and neurosteroid metabolism, playing a crucial role in modulating androgen signaling in tissues such as the prostate, brain, and liver. Dysregulation of AKR1C2 is associated with androgen-driven diseases, including prostate cancer, where its activity can suppress DHT levels and attenuate androgen receptor signaling. AKR1C2 also metabolizes progesterone and other steroid intermediates, linking it to reproductive and neuroendocrine functions. Its role in neurosteroid metabolism influences processes like synaptic inhibition, neuroprotection, and stress responses in the brain. Overexpression of AKR1C2 has been reported in cancers and drug-resistant tumors, where it contributes to detoxifying reactive carbonyl species and reducing chemotherapeutic efficacy. As a result, AKR1C2 is considered a therapeutic target for prostate cancer and neurodegenerative disorders.
Productos relacionados
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Antibody
Rabbit polyclonal antibody against AKR1C2 protein. Immunogen region is Internal.…
Ver producto
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Antibody (Biotin)
Aldo-keto reductase family 1 member C2 Antibody (Biotin) is a Rabbit Polyclonal antibody against Aldo-keto reductase fam…
Ver producto
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) Antibody (FITC)
Aldo-keto reductase family 1 member C2 Antibody (FITC) is a Rabbit Polyclonal antibody against Aldo-keto reductase famil…
Ver producto