Human Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) ELISA Kit

Este producto es parte de AKR1C- Aldo-keto reductase family 1 member C
Human Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) ELISA Kit
715€ (96 tests)

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Name
Human Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx151265
Tested Applications
ELISA

Description

Human Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Dihydrodiol Dehydrogenase 2 (DDH2) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Dihydrodiol Dehydrogenase 2 (DDH2)

Documentos del producto

Instrucciones
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Data sheet
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Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
< 0.06 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-12 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
AKR1C2,DDH2
Background
Elisa Kits for: AKR1C2
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

AKR1C2, known as 3α-hydroxysteroid dehydrogenase, catalyzes the reduction of 5α-dihydrotestosterone (DHT) to 3α-androstanediol, thereby inactivating this potent androgen. AKR1C2 is a key regulator of androgen and neurosteroid metabolism, playing a crucial role in modulating androgen signaling in tissues such as the prostate, brain, and liver. Dysregulation of AKR1C2 is associated with androgen-driven diseases, including prostate cancer, where its activity can suppress DHT levels and attenuate androgen receptor signaling. AKR1C2 also metabolizes progesterone and other steroid intermediates, linking it to reproductive and neuroendocrine functions. Its role in neurosteroid metabolism influences processes like synaptic inhibition, neuroprotection, and stress responses in the brain. Overexpression of AKR1C2 has been reported in cancers and drug-resistant tumors, where it contributes to detoxifying reactive carbonyl species and reducing chemotherapeutic efficacy. As a result, AKR1C2 is considered a therapeutic target for prostate cancer and neurodegenerative disorders.

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