Human Aldehyde Dehydrogenase 6 Family, Member A1 (ALDH6A1) CLIA Kit
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Description
Human Aldehyde Dehydrogenase 6 Family, Member A1 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.
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Product specifications
| Category | CLIA Kits |
| Immunogen Target | Aldehyde Dehydrogenase 6 Family, Member A1 (ALDH6A1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.058 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ALDH6A1,MMSDH |
| Background | CLIA Kits ALDH6A1 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALDH6A1, also known as methylmalonate semialdehyde dehydrogenase (MMSDH), is a mitochondrial enzyme involved in the catabolism of branched-chain amino acids (valine and thymine) and odd-chain fatty acids. It catalyzes the oxidation of methylmalonate semialdehyde to propionyl-CoA, which is further metabolized into succinyl-CoA, linking amino acid breakdown to the TCA cycle. ALDH6A1 plays a critical role in energy metabolism and maintaining metabolic flexibility during nutrient stress. Dysregulation of ALDH6A1 impairs amino acid and fatty acid metabolism, contributing to metabolic disorders, including methylmalonic aciduria and neurological deficits. Its activity is essential for detoxifying reactive intermediates formed during amino acid catabolism, protecting cells from oxidative stress. ALDH6A1 is particularly important in tissues with high metabolic demands, such as the liver, muscles, and brain.
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