Human Aldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1) Enzyme
234€ (2 µg)
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Name
Human Aldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1) Enzyme
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073768
Tested Applications
SDS-PAGE
Description
Aldehyde Dehydrogenase 3 A1 is a recombinant enzyme.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Aldehyde Dehydrogenase 3 Family Member A1 (ALDH3A1) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P30838 |
| Alias | ALDH3A1,ALDH3,ALDHIII |
| Background | Protein ALDH3A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDH3A1 is a cytosolic enzyme that metabolizes aldehydes derived from lipid peroxidation, environmental toxins, and chemotherapeutic agents. It is highly expressed in the cornea, where it protects ocular tissues from UV-induced oxidative stress and maintains transparency. ALDH3A1 detoxifies reactive aldehydes such as 4-HNE and malondialdehyde, preventing protein and DNA damage under oxidative conditions. It also contributes to cellular antioxidant defenses by generating NADPH, which supports glutathione regeneration. Overexpression of ALDH3A1 has been observed in various cancers, where it promotes resistance to chemotherapy and radiation by neutralizing toxic aldehydes. ALDH3A1’s ability to regulate cell proliferation and survival makes it a target for cancer therapy, particularly in chemoresistant tumors. In addition, its role in protecting ocular tissues highlights its therapeutic potential for preventing UV-induced eye damage and cataract formation.
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