Human Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385702
tested applications
ELISA
Description
Human Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldehyde Dehydrogenase 1 Family, Member L2 (ALDH1L2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family Member L2 (ALDH1L2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Sensitivity | < 0.28 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q3SY69 |
| Gene ID | 160428 |
| OMIM | 613584 |
| Alias | Mitochondrial 10-FTHFDH |
| Background | Elisa kits for ALDH1L2 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALDH1L2 is the mitochondrial isoform of 10-formyltetrahydrofolate dehydrogenase and plays a critical role in mitochondrial one-carbon metabolism. It catalyzes the oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate, producing NADPH, which supports mitochondrial redox balance and biosynthetic processes. ALDH1L2 is essential for maintaining nucleotide synthesis, amino acid metabolism, and methylation pathways within the mitochondria, particularly during high energy and biosynthetic demands. Its function in producing NADPH also makes it critical for detoxifying reactive oxygen species (ROS) and protecting cells from oxidative stress. Dysregulation of ALDH1L2 has been implicated in metabolic diseases, neurodegenerative conditions, and cancer. In cancer, loss of ALDH1L2 contributes to metabolic reprogramming, where mitochondrial folate metabolism is disrupted to favor rapid proliferation and tumor growth. Recent studies indicate that ALDH1L2 could serve as a therapeutic target for rebalancing mitochondrial metabolism and reducing oxidative stress in cancer cells.
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